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In 1998, Stanley CA et al

The results showed a progressive increase in MAT2A-positive staining from normal tissues to advanced OS tissues

An ischemia-reperfusion injury can be caused, for example, by a natural event (e.g., restoration of blood flow following a myocardial infarction), a trauma, or by one or more surgical procedures or other therapeutic interventions that restore blood flow to a cell, tissue, and/or organ that has been subjected to a diminished supply of blood

Taken together, our results provide a previously unidentified mechanism by which glutamine supplementation inhibits melanoma tumour growth and suggests a previously unrealized therapeutic avenue using glutamine supplementation in melanoma to cooperate with current therapies and potentially combat resistance mechanisms

Schizophr Res 144 : 18
