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The base mechanism is identical, so if the modified versions really do achieve substantially higher effective tissue concentrations per administered milligram, then a lower administered dose makes sense

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[DOI] [PubMed] [Google Scholar] 242.Chitraju C, Mejhert N, Haas JT, Diaz-Ramirez LG, Grueter CA, Imbriglio JE, et al

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