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[PubMed: 20026785] 888
For kidney injuries, SOX4 was found to upregulate in AKI and was abundantly enriched in the proximal tubules [50]
Conversely, mitigating oxidative stress specifically in HCs (via Gpx4 overexpression) reduced ERK phosphorylation in SCs, likely through EGFR signaling across the SC membrane, leading to GSDMD activation

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