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40,41,42 Studies have proved that NADPH production is dramatically increased by enhancing the flux of glucose into the PPP oxidative branch in various cancers

Interestingly, recent studies have shown that the existence of GSH-GPX4 and ACSL4 independent mechanisms can promote ferroptosis [59]

In this context, two bridged tetrahydroisoquinolines 23 and 24 (CPP-11G and CPP-11H, respectively) were identified as selective NOX2 inhibitors (IC 50 of 20 and 32 M, respectively) with lower IC 50 values claimed in a cell-free system (approximately 30 nM), even if these data were not shown in the paper

For heme iron (around 25% of the total), hydrolysis from hemoglobin/myoglobin is a crucial step before absorption, involving digestion in the gastric and small intestine by proteases

Stiff-person syndrome, first described by Moersch and Woltman in 1956 as stiff-man syndrome, is an autoimmune neurologic disorder characterized by progressive muscle rigidity and spasms, mainly in the truncal and proximal leg muscles