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doi: 10.1007/s11357-000-0022-9

Seed Oil and Fatty Acid Content in Okra (Abelmoschus esculentus) and Related Species

The N-terminal PER moiety harbours most of the known functional domains, including two PER-ARNT-SIM (PAS) domains and an NLS sequence, but it lacks the CLK/CYC inhibition domain and thus does not replace endogenous PER function 27

De Gruyter

In preclinical models of obesity, hypoxia-driven endothelial dysfunction promotes systemic insulin resistance through chronic inflammation 56,57 , excessive macrophage infiltration 58 , immune cell polarization toward a proinflammatory phenotype 59 , and ECM remodeling 60 , ultimately impairing adipocyte function and exacerbating metabolic dysregulation