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Of note, GFAP is produced by activated astroglia that release ROS and pro-inflammatory mediators, creating a vicious cycle between oxidative stress and inflammation and hence playing a vital role in neuroinflammation with its subsequent neuronal apoptosis and hence neuronal damage (Colombo and Farina 2016)

PMC 2583103

GPx catalyses the reduction of hydrogen peroxide, which is produced by superoxide dismutase (SOD) through the dismutation of superoxide anions or organic hydroperoxides

doi: 10.1007/s00134-015-3771-8 75 GoldPW

Medications for the treatment of dopaminergic symptoms include encompassing DA replacement therapy, peripheral 3,4-Dihydroxyphenylalanine (DOPA) decarboxylase inhibitors (DCI), DA receptor (DR) agonists, MAO-B inhibitors, and catechol-O-methyltransferase (COMT) inhibitors