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Genetic variants of AGXT (alanine glyoxylate aminotransferase) gene coding for alanine glyoxylate aminotransferase (i.e., an enzyme involved in oxalate metabolism) have been correlated with the severity of CIPN in patients on oxaliplatin therapy [26]

e impact of these dierences on GSH remains to be elucidated

Glutathione Supports Liver Detoxification Detoxification is not just some trendy word on a bottle

However, bacterial GSTZs lacking this cysteine catalyze the same reaction

Subsequently, welldesigned earlyphase clinical trials will be essential to assess safety, dosing, and shortterm biomarker changes before broader use can be considered (see Table 3 for supporting evidence across study types)