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41589_2021_915_MOESM3_ESM.mpeg Supplementary Video 1 Representative movie for 100 ns MD simulation of WT GPX4
This is believed to occur because insulin is an inhibitor of cystathionine -synthase expression, and in the absence of insulin there is higher catabolism of homocysteine through cystathionine and cysteine synthesis (24)
during hypoxia or glucose starvation, AMPK is activated [138]
As the second messenger, cAMP activates a type of enzyme called a protein kinase that is present in the cytosol (Step 5)
