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In mammals, the mtDNA encodes only 37 genes, of which 13 are subunits of the OXPHOS (complexes I, III, IV, and V), two are rRNA genes, and 22 are tRNA genes required for mitochondrial protein synthesis

Thus PPPSPxS phosphorylation exhibits a mirror image of -catenin phosphorylation in sequential order, in priming requirement, and importantly in functionality, but apparently by the same Axin-GSK3 complex (Huang and He, 2008) (Figure 5)

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Upon binding, CD226 acts through VAV1 to induce ERK signaling critical in augmenting TCR activation and perhaps natural killer cell activation (92, 93)