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Mechanistically, we reveal that VRK2 inhibition disrupts endoplasmic reticulum (ER)-to-Golgi trafficking of SLC7A11, consequently diminishing GSH biosynthesis and predisposing PC cells to ferroptosis
Another significant metformin side effect: vitamin B12 deficiency
Additional trihydroxy acids of this and related types have been prepared using chemo-enzymatic methods, 430,434 and by total chemical synthesis
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H.SoleimaniN.RingE
