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Mangiferin directly binds to Keap1, activates the downstream Nrf2/SLC7A11/GPX4 pathway, inhibits osteoblast ferroptosis, promotes bone formation and improves osteoporosis in ovariectomized mice and iron overload mice

[DOI] [PMC free article] [PubMed] [Google Scholar] 27.Johnson S., Imai S

3.2 Terpenoids Tanshinone is the primary lipophilic bioactive component of the Chinese herbal medicine derived from the rhizome of Salvia miltiorrhiza , serving as a significant intersection between traditional Chinese medicine and advanced molecular biology

Although many P450 crystal structures have now been characterized in mammals, fungi and bacteria, no plant P450 structures have yet been solved 47

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