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Since the pentameric CRP is a substrate for the creation of monomeric CRP, the relative level of pentameric CRP measured in the bloodstream partially depends on the rate at which pentameric CRP is converted into monomeric CRP, which depends mainly on intra-subunit disulfide bonds that determine the conversion and structural stability of CRP isoforms [73]

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Doses above 2ml per injection show diminishing returns: a 2019 study published in the Journal of Clinical Endocrinology found no additional improvement in hepatic fat fraction when methionine doses exceeded 50mg per injection, and injection site soreness increased proportionally above this threshold