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The conversion into tyrosine is tightly regulated by the enzyme phenylalanine hydroxylase (PAH), an enzyme that requires tetrahydrobiopterin (BH 4 ) as a cofactor, and molecular dioxygen as a substrate (Kaufman, 1958

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66 HIF1 is one part of the HIF heterodimeric complex, which is also composed of the HIF1 subunit

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