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Lowering estradiol levels within the male physiological range is associated with an increase in levels of LH, FSH and testosterone [87, 88], as observed in the current study and found to be reversible with cessation of treatment
[DOI] [PubMed] [Google Scholar] 104.Polydefkis, M., Hauer, P., Griffin, J
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Taken together, the combined burden of on-target toxicity and off-target effects constrains the therapeutic window and constitutes a practical barrier to clinical development, making it essential to pair analog optimization with delivery strategies that confine exposure to lesions and minimize unintended pathway engagement in normal tissues
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