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Heparin, a key active component of the ECM, plays crucial roles in biological processes such as growth factor binding and release, anticoagulation, immune regulation, and promoting cell migration and differentiation [67]

Method of Residual The value for k a cannot be obtained directly from the plasma-level time curve for the drug administered by oral route as we calculated the elimination rate constant (k), but it could be obtained using the method of residuals or a feathering technique, which is illustrated in the following graph: On a semilog paper, plot the relation between plasma drug concentrations versus time

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