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Description

Mass spectrometry Mass spectrometry (MS) analysis was carried out on a 4500 QTRAP triple quadrupole/linear ion trap (LIT) hybrid mass spectrometer (Applied Biosystems/Sciex, Toronto, Canada)

According to still another embodiment of the present invention, the peptide Ac-Nle-cyc/o(- Asp-His-D-Phe-Arg-Trp-Lys)-OH is used for the manufacture of a medicament for treatment by multiple agent therapy with a PDE-5 inhibitor for sexual dysfunction, wherein the amount of each of the peptide Ac-Nle-cyc/o(-Asp-His-D-Phe-Arg-Trp-Lys)-OH and the PDE-5 inhibitor is not sufficient, if administered as monotherapy, to independently initiate the desired pharmacological response in the patient

Acidosis resulting mainly from dietwhich can trigger it directly or indirectlycan trigger bacterial transformations, which in turn can boost acidosis mostly via their products and infections (positive feedback loop)