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Similar findings have been observed in rat models of vincristine, oxaliplatin and bortezomib-induced CIPN such that neuropathic pain behaviors were associated with IENF degeneration in the absence of peripheral nerve axonal degeneration (Aley et al., 1996

BRD4 binding motifs in SIM1 or SIM1-Me, VHL E3 ligase binding motifs, and linkers are colored as red, blue, and black, respectively
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Wu Z, Hu H, Wang C, et al