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The signaling cascade involved in the desensitization of GPCRs employed Src to phosphorylate PDK1 at S241, thereby promoting the activation of Akt by facilitating its phosphorylation on T308 (Fig
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Treated mice showed improved Morris water maze performance reduced escape latency emerging across roughly days 45 of the training protocol alongside increased synaptophysin and reduced inflammatory markers (IL-1, TNF-), reportedly via PI3K/AKT signaling
Amylin regulates appetite, slows gastric emptying, and improves satietykey mechanisms in weight loss
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