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Fibroblasts and the deposition of ECM propagate fibrosis via a positive feedback loop, which leads to lung remodeling, tissue stiffness, and dyspnea [25, 26], as portrayed in Fig

With few exceptions, urethral catheterisation is the most appropriate initial treatment of choice for decompression in acute urinary retention , combined with treatment of the provoking etiology (Curtis et al, 2001

However, more research on the use of apremilast in the treatment of UC and its efficacy is needed, especially given its significant advantage of local rather than systemic action

doi: 10.1007/s12576-017-0547-7, 68