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CD22-targeted CAR T-cell therapy At least 50% of relapses after CD19-targeted CAR T-cell therapy have occurred because of antigen escape, which has been shown to be related to mutations in the CD19 protein that delete the binding sites used by CAR T-cell constructs.[203] Salvage after antigen escape has been documented with cell and immune therapy approaches targeting a second lymphoid antigen, CD22

As a result, it may provide benefits for individuals with brain disorders and memory loss

[DOI] [PubMed] [Google Scholar] 164.Dowd P.S., Kelleher J., Guillou P.J

doi: 10.1016/j.abb.2014.05.001

Higher doses and more complex formulations also increase cost