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The specific target, anti-tumor effect, and clinical progress of these inhibitors targeting NADPH metabolism are also summarized in Tables 1 and 2

In particular, vitamin C increases the efficacy of chemotherapies such as oxaliplatin and irinotecan, of immunotherapies, including checkpoint inhibitors anti-CTLA-4 and anti-PD-1, and of EGFR inhibitor cetuximab

While the dosages, pharmacological strategies (monotherapy versus augmentation), and long-term risks are not fully evident, NAC appears to be a promising, relatively low-risk intervention

Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age

doi: 10.1016/j.nxmate.2025.101165