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Insulin resistance (IR) refers to the reduced sensitivity and reactivity of insulin target organs (liver, adipose tissue and skeletal muscle) to endogenous or exogenous insulin, resulting in lower glucose uptake and utilization than normal (Haas et al., 2016)

Moreover, the crystal structure of Gbs MerA and structural comparison with homologues indicated that Gbs MerA contains residues, Tyr437 and Asp47, which may be responsible for metal transfer at the si -face by providing a hydroxyl group (OH) to abstract a proton from the thiol group of cysteine

[DOI] [PubMed] [Google Scholar] Guo, X

10.1080/10408390701425615 24 EsterasN.AbramovA

MicroRNA-587 antagonizes 5-FU-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancer