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Advances in metabolite processing methods and metabolite identification tools, such as Bio-Transformer, are expected to further expand the number of annotated metabolites, enhancing the comprehensive coverage enabled by of metabolic databases (Djoumbou-Feunang et al., 2019

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Paradoxically, while iron toxicity in PD is linked to dysfunctional iron metabolism, intragastric delivery of iron carbonyl boosts the biosynthesis of iron-sulfur clusters and elevates aconitase 1 activity, which is crucial for mitochondrial function and iron homeostasis, thereby preventing ferroptosis in vivo (188)

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