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Malaviya AN, Sharma A, Agarwal D, Kapoor S, Garg S, Sawhney S (2010) Low-dose and high-dose methotrexate are two different drugs in practical terms

10.1371/journal.ppat.1007746 11 BeattyG

The intestines do not only form a physical barrier to protect against pathogens but are also home to the largest immune organ of the body: the gut-associated lymphoid tissue (GALT)

Most mild digestive shifts will resolve quickly as your body adapts to the increased antioxidant support