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Description
COMT enzymes are also involved in metabolizing the female hormone estrogen and any gene alteration may cause estrogen dominance
6.7 Research gaps and prioritized next steps Key gaps include limited validated pharmacodynamic biomarkers beyond sulforaphane, lack of standardized and stabilized delivery formulations, incomplete mapping of host proteome S-thiolation to define therapeutic windows, inconsistent combination-testing pipelines, and insufficient field data linking agricultural use to resistome outcomes
"The identity of glutathione S -transferase B with ligandin, a major binding protein of liver"

doi: 10.1186/s13568-020-01066-8
This topic remains an interesting area for future work
