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Molecular dockings were performed on AutoDock Vina 1.2.0 software and CB-DOCK2 website 60,61

Patch Testing: For topical research, conducting a patch test on a small, inconspicuous area of skin (e.g., the inner forearm) is always a recommended step to assess individual skin compatibility before broader application

However, as the pathological microenvironment of the diseased vascular tissue continues to deteriorate, the body gradually loses its self-repair ability, and lipid metabolism pathways become imbalanced, leading to further aggravation of the lesion and falling into a vicious cycle

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Different Types of Topical Formulations Available GHK-Cu is commonly administered in the form of skin creams, hair serums, shampoos, or topical ointments, applied once or twice daily to specific areas like the face for skin tightening, the scalp for hair growth, or other regions for scar or wound healing