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This is a critical part of Phase II detoxification

We agree with the applicant that REZZAYO TM meets the cost criterion and are therefore proposing to approve REZZAYO TM for new technology add-on payments for FY 2024 for use in patients 18 years of age or older who have limited or no alternative options for the treatment of candidemia and invasive candidiasis

Notably, deletion of GPX4 caused severe phenotypic abnormalities in mice in animal experiments, whereas deletion of the ALOX12 gene did not cause major developmental defects in mice

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In these tumors, CHAC1can promote tumor cell survival, proliferation, and invasion, contributing to cancer progression and drug resistance