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This prolonged diagnostic process is compounded by differences in exclusion criteria across various definitions of ME/CFS, as highlighted by Jason et al., 2012 (54)
investigated a folate-conjugated rapamycin (FC-rapa) and showed inhibition of mTOR activity in the kidneys of a Pkd1flox/_: Nestin-Cre murine model at a dose of 0.6 mol/kg/day [161]