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A 2021 review in Biomedicines summarizing evidence from over 100 published studies identified the pentadecapeptides proline-rich configuration and the absence of conventional protease cleavage sites as the primary structural factors the peptide sequence simply lacks the recognition motifs the dominant gastric enzymes rely on

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It was previously observed that while melanoma cell lines take up DHA at much higher rates than vitamin C, normal melanocytes do not, demonstrating that transformation-driven upregulation of GLUTs leads to increased uptake of DHA 3

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