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This temporal rule refines Hebb's postulate by adding a time dimension to input-specific plasticity, highlighting that not just simultaneous activity but the order of spikes can determine whether a connection is potentiated or depressed

Many of the previously published randomized trials focused on digital behavioral therapies for chronic pain have included psychotherapist-delivered guidance in the form of regular feedback, support, clarification, and/or encouragement (Gandy et al., 2022

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