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245,246,247 Liposomal formulations Liposomes are the first generation of drug delivery systems and have been widely used since their discovery in 1965
The intermittent schedule reflects the "hit-and-clear" nature of senolytic therapy -- once apoptosis is triggered, the immune system needs time to phagocytose debris
In this phase, neuroprotective regulatory T-cells significantly decrease, and neurotoxicity predominates (Fig
