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There are other hypotheses for age-related increases in systemic IL-6 concentrations, such as enhanced oxidative damage or chronic viral infestations (i.e., cytomegalovirus and herpes), which are reported in the weak and aged [210]

Since glutaminase 1 (GLS1), a key mitochondrial enzyme that catalyzes the deamidation of glutamine, was first discovered in the kidney in 1958 9 , many enzymes involved in glutamine metabolism have been reported 4

Effective doses spanned six orders of magnitude (10 pg/kg to 10 mcg/kg)

Formation of the active site recruits another GST monomer to interact with the system and the enzymes dimerize

Weirs, M.D., at COEM for Enhanced Immunity and Overall Wellness