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As GABA and glutamate hold opposite effects modulating the neural activity (either decreasing or increasing excitability), it may be possible that the relation of these neurometabolites with GSH derives from the energy supply needed to hold either inhibitory or excitatory connections and not from the energy of neural activity itself

Nevertheless, it has been shown that in the humans, the GST with the highest activity toward AFB 1 exo-epoxide is the polymorphic hGSTM1-1 which is absent in about 50% of individuals in most human populations

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Finkelstein JL, Fothergill A, Venkatramanan S, et al

doi:10.18632/oncotarget.27529