glutathione and sarcomas Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression: Cancer Cell Soft tissue sarcoma metabolic hallmarks.
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Additionally, hyperglycemia has been shown to enhance the repressive histone mark H3K27me3 in human vascular endothelium through upregulation of the methyltransferase EZH2 and suppression of the demethylases UTX/JMJD3, resulting in downregulation of antioxidant genes (e.g., SOD1, SOD2) and elevated NOX4-mediated ROS production [133]
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Cai J, Jiang Y, Ritchie ES, Macho AP, Yu F, Wu D
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