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They only talk about going up, never about going down

The lesion in the original template strand can be bypassed by transiently switching replication to the newly synthesized daughter strand
The metabolism that once tolerated the occasional dessert or skipped workout suddenly becomes far less forgiving

doi: 10.1073/pnas.90.16.7804 68 PetersMCMintonAPhanstiel IvOGilmourSKNovelA

A substantial body of research has demonstrated that prolonged exposure to fine particulate matter (PM2.5), the most significant environmental health risk factor, is strongly associated with the advancement of diseases affecting the cardiovascular system, respiratory system, nervous system, digestive system, and reproductive system
