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Erinacine S induced neurogenesis in both cortical and dorsal root ganglion primary mouse neuron cultures through the enhanced expression of genes encoding for the metabolism of the neurosteroids pregnenolone and progesterone ( In whole-brain mixed glia co-cultures following LPS insult, erinacine C induced the expression of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2), which was correlated with increased protein expression of BDNF and other antioxidant enzymes (Wang et al., 2019)

Abstract Astrocytes have a pivotal role in brain as partners of neurons in homeostatic and metabolic processes

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Cerebral blood flow in normal aging adults: cardiovascular determinants, clinical implications, and aerobic fitness