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Therefore, CIPN is regarded a multifactorial disorder with diverse pharmacological mechanisms, and a number of common pathologies, including altered ion channel functions, oxidative stress, axonal degeneration, impaired calcium homeostasis, neuroinflammation, and activation of the immune system, have been proposed to underlie CIPN development (Fig

NADPH oxidases (NOX) are another source of cellular ROS

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Abdominal pain and cramping Diarrhea, often with pus and blood Rectal bleeding Urgency to defecate Rectal pain Fatigue (due to mitochondrial involvement) Weight loss Fever Failure to grow (in children) Ulcerative colitis can lead to some severe health complications