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doi: 10.1038/gim.2015.186 136

What happens is your body gradually becomes more efficient at mobilizing and burning stored fat

elegans , as this has been studied as a mediator of lifespan extension in multiple studies and organisms [133]

Indeed, compounds such as 5-aza-cytidine and RG108, which are designed to target DNA methylation, are currently being investigated for their potential efficacy in neurodegenerative diseases, such as PD (201)

These susceptibility loci do not act in isolation but converge on core biological pathways governing intestinal homeostasis, including: (1) Autophagy impairment: Mutations in key autophagy-related genes (e.g., ATG16L1, IRGM, and MST1) disrupt cellular autophagy, compromise intracellular bacterial clearance, and may perpetuate inflammatory responses (Gabbani et al., 2017