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Benign metastasis may explain how 4% of melanoma patients develop metastasized melanomas despite the absence of detectable primary tumors ( Figure 3 Angiogenesis Angiogenesis is a biological process that marks a critical stage in tumor progression where the cells transition from an avascular to a vascular phase, serving as a turning point in melanoma tumor growth and metastasis ( Figure 4 )

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Lactate administration increases mRNA expression of PGC-1alpha and UCP3 in mouse skeletal muscle