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Overall, excessive truncation and S129p may create a precarious cellular state, causing widespread and unpredictable cellular consequences by enhancing promiscuous interaction, sequestering essential cellular components, and promoting LB nucleation and growth (Fig
Nature 416: 535539 [DOI] [PubMed] [Google Scholar] Wang XB, Yang Y, Zhou Q 2007
Understanding these molecular changes could reveal novel therapeutic targets aimed at restoring normal astrocytic function and protecting neurons from degeneration (Lalo et al., 2021)
Soleymani M, Velashjerdi M, Asgari M
Chen M, Liu G, Fang Z, Gao W, Song Y, Lei L, et al
