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Lysis of ragged-red fibers might actually be beneficial by inducing satellite cell fusion

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doi: 10.3322/caac.21871 5 AgarwalAGuptaSSharmaRK

We propose a folate-dependent hypermobility syndrome (FDHS) model wherein (1) decreased MTHFR activity derepresses the ECM-specific proteinase matrix metalloproteinase 2 (MMP-2), and subsequently, (2) increases MMP-2-mediated cleavage of the proteoglycan decorin