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Notably, approaches that aim to reprogram TAMs towards an anti-tumor phenotype, such as by promoting macrophage polarization towards an M1-like phenotype or enhancing macrophage-mediated antigen presentation and T cell activation, hold great potential for cancer immunotherapy

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Key finding: AOD 9604 showed superior lipolytic activity (EC50 45 nM) versus native GH (EC50 380 nM) with insulin-independent mechanism