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targeted the IP3 receptor (IP3R) channels and induced the downstream pro-apoptotic Ca 2+ -signaling pathway via synthesizing a peptide named Bcl-2 IP3 receptor disrupter-2 (BIRD-2) mimicking the structure of the BH4 domain of Bcl-2

Recent research has shown that CAFs, a significant group of stromal cells in the TME that emit HGF, trigger the HGF/c-MET pathway and its subsequent signals, thereby facilitating tumor movement and advancement
Lab work for monitoring can cost $100-$500 per panel