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However, a randomized double-blind placebo-controlled trials using 400 mg/day of riboflavin in adolescent patients between 12- and 19-year-old has demonstrated significant positive results in reductions of migraine attack frequency and related disability (100)

Folate, B2 (riboflavin), and B3 (niacin) deficiencies can all cause glossitis

Its also on the World Anti-Doping Agencys prohibited list for professional athletes because of its unproven claims and possible health risks

Atypical PKAN typically presents in the second or third decade with a slow progression of symptoms

Yanagihara, Y., Shiozawa, K., Takai, M., Kyogoku, M