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These investigators used this strategy to generate mouse models of denigrative diseases such as diabetes, wound healing, and progressive deafness (Masato 2011)

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The TSS pathway and xCT both play integral roles in the ISR through ATF4 and the oxidative stress response through NRF2, suggesting that induction of cellular stress by traditional chemotherapeutics could open the possibility of targeting stressed cells through metabolic intervention [30,38,77]

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It works by activating the IGF-1 receptor , a tyrosine-kinase receptor that drives cell growth, proliferation and protein synthesis, which is why it is studied for anabolic and muscle-related effects