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Cold hyperalgesia is a typical side effect of oxaliplatin
Marla et al
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Therefore, antifolates and drugs that target one-carbon metabolism, have been used for treating cancers
Epithelial MLCK-dependent barrier dysfunction mediates T-cell activation-induced diarrhea in vivo Cytoskeletal contraction due to myosin II (regulatory)-light chain (MLC) phosphorylation is necessary for barrier disruption and in vitro inhibition of myosin light chain kinase (MLCK) restores barrier function following cytokine treatment
