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Vitamin B12 Deficiency A Vitamin B12 deficiency can be caused by various factors which include insufficient diet, problems with nutrient absorption, specific medications, and age-related issues

Apostolopoulos, Vitamin B1, B2, B3, B5, and B6 and the Immune System, in Nutrition and Immunity, Cham: Springer International Publishing, 2019, pp

The metabolic support process develops progressively over weeks to months, with optimal results requiring consistent administration alongside proper nutrition and exercise

This could be due to racial differences in B12 metabolism, or in environmental factors, most obviously diet (B12 intake)