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DOI: 10.1016/j.peptides.2005.01.029 Clinical Development Afamelanotide and EPP Afamelanotide (MT-1), delivered as a subcutaneous slow-release implant, has been studied in multiple randomised controlled trials in patients with erythropoietic protoporphyria (EPP)

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On the one hand, TMAO levels are dynamically changing in human circulation (this physiological concentration range is also controversial) and are strictly regulated by factors such as age, diet, gut microbiota composition, hepatic enzyme activity, as well as liver and kidney function