glutathione vs glutathione precursors Targeting Metabolism: Partner in Crime in Anticancer Therapy Glutathione precursor amino acids, permeases

Previously, the patient was seen at his oncology clinic for evidence of cancer progression on his current chemotherapy, rituximab and polatuzumab vedotin, due to an increase in the growth of a bulky tumor on the patients back ( Figure 2 ) The patient was urgently started on a new chemotherapy regimen consisting of ifosfamide, carboplatin and etoposide

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Tumor-intrinsic activity of chromobox 2 remodels the tumor microenvironment in high-grade serous carcinoma

doi: PubMed: 18025101

In the clinical trials of treatment of GC with apatinib combined with docetaxel, the mPFS and mOS of the apatinib group and the combination group were 2.5 and 4 months, 3.3 and 6 months, respectively, and grade 3/4 adverse reactions such as neutrophils, cytopenia, anemia, thrombocytopenia, and hypertension were milder in the combination group than in the apatinib group (128)