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Such findings underscore the significance of microbial metabolites as potent bioactive molecules that can be harnessed to boost immunotherapeutic strategies and support tissue regeneration in chronic diseases

PhoPQ influences the modification of LPS, including the attachment of l-Ara4N, both directly and indirectly

Submicromolar concentrations of 4-hydroxynonenal induce glutamate cysteine ligase expression in HBE1 cells

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Small molecule erastin can directly and selectively target and inhibit the System X c , and irreversibly bind to and inactivate XCT, leading to continuous disorder of cystine uptake, a decrease in cellular antioxidant capacity, and eventually ROS accumulation and ferroptosis (Sato et al., 2018